IIT-M researchers identify role of microRNA in tongue cancer
Chennai: Indian Institute of Technology Madras (IIT-M) on Monday mentioned its researchers have recognized a particular microRNA (miRNAs) known as `miR-155 that’s over-expressed in tongue most cancers.
According to the researchers, miRNAs have an effect on most cancers progress by inhibiting or enhancing the capabilities of sure proteins. For instance, it has been seen {that a} kind of protein known as `programmed cell dying 4` –pdcd4– helps in stopping most cancers cells from rising and spreading.
Inhibition of this protein has been identified to trigger the unfold of oral, lung, breast, liver, mind and colon cancers.
For the present research, IIT Madras collaborated with researchers from Cancer Institute and Sree Balaji Dental College and Hospital at Chennai and Indian Institute of Science at Bengaluru.
“MicroRNAs (miRNAs) are short non-coding RNAs containing 20?24 nucleotides that participate in virtually all biological pathways in animals,” research lead researcher Devarajan Karunagaran, Head, Department of Biotechnology, IIT Madras, mentioned in a press release.
“They have been found to play important roles in many cancers, in carcinogenesis (start of cancer), malignant transformation and metastasis – the development of secondary cancer. The miRNAs associated with cancer are called `Oncomirs`,” Karunagaran added.
According to the researchers, most of the oncomirs have an effect on most cancers by suppressing the efficiency of tumour suppressing brokers that may stop progress and unfold of most cancers cells, though some oncomirs are additionally concerned in stopping tumour progress itself.
It is due to this fact vital to determine the forms of miRNAs which can be related to each suppression and proliferation of most cancers cells.
For the findings, revealed within the peer-reviewed journal Molecular and Cellular biology, the analysis group went past exhibiting the connection between miR-155 and pdcd4.
They have additionally proven that knocking out miR-155 causes dying of most cancers cells, arrests the cell cycle, and regresses tumour dimension in animal fashions and reduces cell viability and colony formation in benchtop assays.
“While it has been long suspected that miR-155 downregulates Pdcd4, there have, hitherto, been no evidence for such interaction,” mentioned research researcher Shabir Zargar.
The analysis group has proven past doubt that miR-155 is overexpressed in tongue most cancers cells and tongue tumour tissues.
This `overactivity` of miR-155 hinders the motion of pdcd4, which in flip causes unfold and progress of most cancers of the tongue.
“Our study has shown that the restoration of Pdcd4 levels through molecular manipulation of miR-155 can lead to potential therapeutic developments for cancers, especially of tongue cancer,” Karunagaran added.
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